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. Author manuscript; available in PMC: 2018 Feb 9.
Published in final edited form as: J Med Chem. 2016 Dec 20;60(3):839–885. doi: 10.1021/acs.jmedchem.6b00788

Table 5.

Cytotoxicity of Arglabin and Derivatives Towards Cancer Cell Lines

Cell line a 203 205 208 209 210 211 212
515A2 (melanoma) 6.72 5.54 16.9 16.9 13.2 14.3 15.0
A431 (cervical) 4.48 5.19 12.8 13.6 16.9 18.9 4.40
A549 (lung) 2.21 1.95 12.8 10.1 4.76 4.76 15.7
HT-29 (colon) 7.00 10.8 18.6 17.8 16.2 8.1 15.1
MCF-7 (breast) 2.33 1.85 17.3 16.9 13.4 16.9 15.1
a

IC50 values reported in μM