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. Author manuscript; available in PMC: 2018 Feb 7.
Published in final edited form as: Circulation. 2017 Feb 7;135(6):578–589. doi: 10.1161/CIRCULATIONAHA.116.025954

Table 3.

Hazard ratios (95% confidence intervals) for preterm delivery in first pregnancy and cardiovascular events (MI and stroke), among women without hypertensive disorders of pregnancy in first pregnancy

Non-HDP Term: ≥37 weeks (n=51,343) Non-HDP Preterm: <37 weeks (n=4,487) Non-HDP Moderate Preterm: ≥32 to <37 weeks (n=3,372) Non-HDP Very Preterm: <32 weeks (n=1,115)
Cases/Person-Years* 613/1,641,456 76/141,478 46/105,585 30/35,893

Model 1 1.00 (ref) 1.44 (1.13, 1.82) --- ---
Model 2 1.00 (ref) 1.38 (1.08, 1.75) --- ---
Model 3 1.00 (ref) 1.35 (1.06, 1.72) --- ---

Model 1 1.00 (ref) --- 1.17 (0.87, 1.58) 2.21 (1.53, 3.18)
Model 2 1.00 (ref) --- 1.15 (0.85, 1.55) 2.02 (1.39, 2.95)
Model 3 1.00 (ref) --- 1.12 (0.83, 1.52) 2.01 (1.38, 2.93)

Model 1 is adjusted for age at first birth, age in 1989, race/ethnicity, and parental education

Model 2 is additionally adjusted for pre-pregnancy BMI, pre-pregnancy smoking, pre-pregnancy Alternative Healthy Eating Index (AHEI) score (in quintiles), pre-pregnancy alcohol intake, physical activity at age 18, and pre-pregnancy oral contraceptive use

Model 3 is additionally adjusted for pre-pregnancy chronic hypertension, pre-pregnancy hypercholesterolemia, pre-pregnancy type 2 diabetes mellitus, and family history of MI or stroke before age 60

*

Sample size and total case numbers differ from Table 2 due to additional exclusion criterion: did not complete 2009 reproductive wrap up. The 2001 questionnaire did not include questions regarding HDP.

Compares non-HDP preterm (<37 weeks) to Non-HDP term (≥37 weeks)

Non-HDP preterm category is split into non-HDP moderate preterm (≥32 to <37 weeks) and non-HDP very preterm (<32 weeks)