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. 2017 Feb 7;10:691–701. doi: 10.2147/OTT.S112223

Figure 6.

Figure 6

Effects of ARHGAP1 on the protein expressions of MMP2, ZEB1, CCNB1, Twist and PCNA in C-33A and SiHa cells.

Notes: (A) ARHGAP1 overexpression evidently decreased the mRNA expression of all the genes in C-33A cells. (B) The protein levels of all the proteins were declined in C-33A cells. (C) ARHGAP1 overexpression evidently decreased the mRNA expression of all the genes in SiHa cells. (D) The protein levels of all the proteins were declined in SiHa cells. (E) ARHGAP1 knockdown evidently increased the mRNA expression of all the genes in HeLa cells. (F) The protein levels of all the proteins were increased in HeLa cells. n=3, mean ± SD. **P<0.01, ***P<0.001 vs control groups.

Abbreviations: CCNB1, Cyclin B1; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; MMP2, matrix metallopeptidase 2; PCNA, proliferating cell nuclear antigen; NC, negative control; shNC, shRNA-NC; Twist, twist family bHLH transcription factor 1; ZEB1, zinc finger E-box binding homeobox 1.