Table 1.
Association between the expression of Kindlin proteins and various clinicopathologic features of osteosarcoma patients
| Clinicopathologic features | No of cases, n (%) | Kindlin-1-high, n (%) | P-value | Kindlin-2-high, n (%) | P-value | Kindlin-3-high, n (%) | P-value |
|---|---|---|---|---|---|---|---|
| Age (years) | |||||||
| <18 | 40 (40.00) | 20 (50.00) | NS | 21 (52.50) | NS | 22 (55.00) | NS |
| ≤18 | 60 (60.00) | 32 (53.33) | 30 (47.50) | 28 (45.00) | |||
| Sex | |||||||
| Male | 68 (68.00) | 36 (52.94) | NS | 35 (51.47) | NS | 38 (55.88) | NS |
| Female | 32 (32.00) | 16 (47.06) | 16 (47.06) | 12 (44.12) | |||
| Tumor site | |||||||
| Femur | 55 (55.00) | 29 (52.73) | NS | 28 (50.91) | NS | 27 (49.09) | NS |
| Tibia | 20 (20.00) | 10 (50.00) | 11 (55.00) | 10 (50.00) | |||
| Humeral bone | 15 (15.00) | 8 (53.33) | 7 (46.67) | 8 (53.33) | |||
| Other | 10 (10.00) | 5 (50.00) | 5 (50.00) | 5 (50.00) | |||
| Histologic type | |||||||
| Osteoblastic | 55 (55.00) | 29 (52.73) | NS | 28 (50.91) | NS | 27 (49.09) | NS |
| Chondroblastic | 20 (20.00) | 10 (50.00) | 11 (55.00) | 10 (50.00) | |||
| Fibroblastic | 15 (15.00) | 8 (53.33) | 7 (46.67) | 8 (53.33) | |||
| Telangiectatic | 10 (10.00) | 5 (50.00) | 5 (50.00) | 5 (50.00) | |||
| Tumor grade | |||||||
| Low | 15 (15.00) | 3 (20.00) | 0.01 | 4 (26.67) | 0.01 | 6 (40.00) | NS |
| High | 85 (85.00) | 49 (57.64) | 47 (55.29) | 44 (51.76) | |||
| Metastasis | |||||||
| Absent | 60 (60.00) | 20 (33.33) | 0.006 | 21 (35.00) | 0.006 | 27 (45.00) | NS |
| Present | 40 (40.00) | 32 (80.00) | 30 (75.00) | 23 (57.50) | |||
| Recurrence | |||||||
| Absent | 70 (60.00) | 27 (38.57) | 0.006 | 28 (40.00) | 0.006 | 34 (48.57) | NS |
| Present | 30 (40.00) | 25 (83.33) | 23 (76.67) | 16 (53.33) | |||
| Response to preoperative chemotherapy | |||||||
| Good | 50 (50.00) | 19 (38.00) | 0.02 | 18 (36.00) | 0.02 | 21 (42.00) | NS |
| Poor | 50 (50.00) | 33 (66.00) | 33 (66.00) | 29 (58.00) | |||
Abbreviation: NS, not significant.