Figure 6.

The microscopic hematoxylin-and-eosin histology slides of liver for toxicity assessment of selected mice.

Notes: Mice were treated with 3.125 μg kg⁻¹ bw of GW in TA (A), TB (B), TC (C), TD (D), CN (E) and CI (F) groups. TA stands for acute exposure without infection, TB stands for acute exposure immediately within 2 hours after infection, TC represents subacute exposure without infection and TD stands for subacute exposure immediately within 2 hours after infection; CN, normal control mice without any infection and treatment; CI, single-dose infected normal mice. No sign of toxic effects in the liver were observed for all groups of mice treated with 3.125 μg kg⁻¹ bw of GW. This included structural degeneration of hepatocytes, presence of Kupfer cells, as well as increased number of mitotic figures. The hepatocytes seemed intact while the sinusoids were not congested. Microscopic images were viewed at 100× magnification.

Abbreviations: bw, body weight; GW, gancidin W.