Table 5.
Sputum gene expression of interleukin 1 pathway genes in participants with prior year frequent versus nonfrequent exacerbations
| Marker | COPD+Asthma
|
COPD
|
Asthma
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Frequent | Nonfrequent | P-value | Frequent | Nonfrequent | P-value | Frequent | Nonfrequent | P-value | |
| n | 34 | 61 | 26 | 34 | 8 | 27 | |||
| IRAK2 | 1.02 (2.10) | 2.89 (1.98) | <0.001 | 0.85 (2.15) | 2.58 (2.14) | 0.003 | 1.58 (1.97) | 3.28 (1.72) | 0.023 |
| IRAK3 | 4.21 (2.18) | 6.94 (1.87) | <0.001 | 4.03 (2.18) | 6.62 (1.85) | <0.001 | 4.76 (2.28) | 7.34 (1.86) | 0.003 |
| PELI1 | 2.50 (1.54) | 4.27 (1.53) | <0.001 | 2.35 (1.41) | 3.91 (1.52) | <0.001 | 3.00 (1.93) | 4.73 (1.45) | 0.010 |
| IL1R1 | 4.66 (1.73) | 6.76 (1.98) | <0.001 | 4.68 (1.58) | 6.30 (1.82) | <0.001 | 4.60 (2.26) | 7.32 (2.07) | 0.003 |
| IL1R2 | 3.96 (3.11) | 5.40 (1.93) | 0.007 | 4.11 (3.47) | 5.02 (1.97) | 0.202 | 3.46 (1.50) | 5.86 (1.81) | 0.002 |
| IL1RN | 1.48 (3.91) | 1.83 (1.66) | 0.549 | 1.93 (4.12) | 1.67 (1.86) | 0.747 | 0.01 (2.89) | 2.02 (1.37) | 0.009 |
| IL1A | 6.01 (2.28) | 6.83 (1.68) | 0.050 | 5.68 (2.27) | 6.96 (2.00) | 0.024 | 7.23 (2.05) | 6.67 (1.18) | 0.344 |
Notes: Data expressed as the change in cycle threshold (Ct) compared with the housekeeping gene β-actin (ΔCt), mean (standard deviation). A lower ΔCt corresponds to a stronger expression of the target gene.