Table 1. Distribution of demographic and clinical factors by PON1 Q192R phenotype among in vitro fertilization patients (n = 171).
Factor | PON1 Q192R phenotype | |||||
---|---|---|---|---|---|---|
QQ (n = 70) | QR (n = 73) | RR (n = 28) | ||||
n | % | n | % | n | % | |
Age (years) | ||||||
< 35 years old | 26 | 54.2 | 18 | 37.5 | 4 | 8.3 |
≥ 35 years old | 44 | 35.8 | 55 | 44.7 | 24 | 19.5 |
BMI (kg/m2) | ||||||
< 25 | 51 | 46.4 | 42 | 38.2 | 17 | 15.5 |
25–29 | 13 | 31.0 | 22 | 52.4 | 7 | 16.7 |
≥ 30 | 6 | 31.6 | 9 | 47.4 | 4 | 21.1 |
Race a, * | ||||||
non-Asian | 56 | 48.7 | 47 | 40.9 | 12 | 10.4 |
Asian | 7 | 14.9 | 25 | 53.2 | 15 | 31.9 |
Cigarette smoking b | ||||||
Never | 56 | 38.4 | 64 | 43.8 | 26 | 17.8 |
Ever | 9 | 47.4 | 8 | 42.1 | 2 | 10.5 |
Diagnosis | ||||||
Male factor | 28 | 45.2 | 26 | 41.9 | 8 | 12.9 |
Unexplained c | 18 | 37.5 | 18 | 37.5 | 12 | 25.0 |
Female factor-non DOR d | 13 | 43.3 | 14 | 46.7 | 3 | 10.0 |
Female factor-DOR | 9 | 33.3 | 14 | 51.9 | 4 | 14.8 |
PGD-only | 2 | 50.0 | 1 | 25.0 | 1 | 25.0 |
COS protocol | ||||||
Lupron down regulated | 48 | 41.7 | 48 | 41.7 | 19 | 16.5 |
Antagonist | 18 | 42.9 | 17 | 40.5 | 7 | 16.7 |
Flare | 4 | 28.6 | 8 | 57.1 | 2 | 14.3 |
a n = 9 missing values;
b n = 6 missing values;
c includes n = 1 recurrent pregnancy loss;
d includes n = 10 endometriosis, n = 10 tubal factor, n = 7 polycystic ovary syndrome and n = 3 anovulation;
* P < 0.05 for across PON1 Q192R phenotypes.
BMI, body mass index; COS, controlled ovarian stimulation; DOR, diminished ovarian reserve; FF, follicular fluid; PGD, pre-implantation genetic diagnosis.