Table 3. Multivariable linear regression models of follicular fluid (FF) and serum PON1 activities associated with high-density lipoprotein (HDL) particles (μmol/L), according to PON1 Q192R phenotype.
PON activity | Phenotype | HDL particles | FF a | Serum | ||||
---|---|---|---|---|---|---|---|---|
% change | 95% CI | % change | 95% CI | |||||
Low | High | Low | High | |||||
Arylesterase activity | Large | 1.22 * | 1.14 | 1.31 | 1.11 | 0.88 | 1.40 | |
Medium | 1.34 * | 1.21 | 1.49 | 1.14 | 0.98 | 1.31 | ||
Small | 1.64 * | 1.46 | 1.84 | 0.99 | 0.89 | 1.10 | ||
QR | Large | 1.12 * | 1.01 | 1.25 | 1.25 | 0.87 | 1.81 | |
Medium | 1.40 * | 1.19 | 1.64 | 1.24 * | 1.02 | 1.52 | ||
Small | 1.92 * | 1.65 | 2.24 | 1.24 * | 1.07 | 1.45 | ||
RR | Large | 1.20 * | 1.06 | 1.35 | 1.11 | 0.67 | 1.83 | |
Medium | 1.43 * | 1.31 | 1.56 | 1.00 | 0.63 | 1.58 | ||
Small | 1.55 * | 1.33 | 1.80 | 1.30 | 0.81 | 2.10 | ||
Paraoxonase activity | Large | 1.13 * | 1.04 | 1.22 | 1.43 * | 1.12 | 1.81 | |
Medium | 1.32 * | 1.20 | 1.46 | 1.21 * | 1.04 | 1.41 | ||
Small | 1.70 * | 1.53 | 1.90 | 1.04 | 0.93 | 1.17 | ||
QR | Large | 1.11 * | 1.04 | 1.19 | 1.41 | 0.89 | 2.24 | |
Medium | 1.33 * | 1.23 | 1.44 | 1.32 * | 1.02 | 1.70 | ||
Small | 1.74 * | 1.59 | 1.91 | 1.27 * | 1.05 | 1.54 | ||
RR | Large | 1.24 * | 1.14 | 1.36 | 1.80 * | 1.16 | 2.77 | |
Medium | 1.58 * | 1.46 | 1.69 | 1.25 | 0.83 | 1.86 | ||
Small | 1.57 * | 1.37 | 1.80 | 1.19 | 0.78 | 1.79 |
NOTE: PON enzyme activities and concentrations of HDL particles were natural log-transformed for the analyses. Models were adjusted for age, body mass index, and cigarette smoking.
a Generalized estimating equations were used to provide robust standard errors;
* indicates P < 0.05; CI, confidence interval.