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. 2016 Aug 22;7(38):60858–60871. doi: 10.18632/oncotarget.11504

Figure 3. Effect of BRAF-i and MEK-i on NK cell proliferation.

Figure 3

Proliferative responses of NK cells isolated from 4 healthy donors cultured for 6 days with IL-2, IL-15 or IL-15/18 either in the absence (DMSO) or in the presence of PLX4032 or PD0325901 (10 μM). A. Representative flow cytometric analysis showing proliferating NK cells either untreated (red profiles) or exposed to PLX4032 (blue profiles) or PD0325901 (black profiles) expressing Ki67 are shown. Numbers indicate the percentages of proliferating cells. B. Statistical analysis of NK cell proliferation induced by cytokines in the absence or in the presence of BRAF-i (PLX4032) or MEK-i (PD0325901). Data are shown as means ± SD. Data are representative of 4 independent experiments. **, p < 0.01*, p ≤ 0.05; n.s., not significant by two tailed paired Student's t test.