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. 2016 Aug 13;7(38):61166–61182. doi: 10.18632/oncotarget.11278

Figure 2. High miR-4653-3p level was associated with better disease-free survival following tamoxifen in breast cancer patients.

Figure 2

MiR-4653-3p levels in primary tumor tissues from the validation cohort were detected by real-time RT-PCR. Estimated Kaplan-Meier disease-free survival curves of patients with high (≥ 0.43) and low (< 0.43) expression of miR-4653-3p were compared. The optimal cutoff value for miRNA-4653-3p level was determined by ROC curve. Hazard ratio (HR) was adjusted by age at diagnosis, tumor size, lymph node involvement, Ki67 expression, HER2 status, menopause status when receiving tamoxifen and adjuvant chemotherapy. P values were calculated using a log-rank analysis.