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. 2016 Aug 17;7(38):61284–61294. doi: 10.18632/oncotarget.11343

Table 2. Summary of meta-analysis results for the numbers of dissected lymph nodes and bladder cancer outcomes.

Analysis specification Highest category vs. lowest category
Studies SRRE (95% CI) p−het I2
Overall survival
All 13 0.72 (0.64−0.80) 0.000 67.2
Year of publication
 ≥ 2011 9 0.75 (0.66−0.84) 0.000 71.7
 < 2011 4 0.61 (0.49−0.76) 0.663 0.0
Sample size (cases)
 ≥ 500 8 0.74 (0.67−0.83) 0.003 68.0
 < 500 5 0.66 (0.48−0.91) 0.029 62.8
Mean age (years)
 ≥ 65 10 0.72 (0.64−0.81) 0.000 69.8
 < 65 3 0.76 (0.53−1.11) 0.052 66.2
Geographical region
 America 7 0.74 (0.69−0.80) 0.539 0.0
 Europe 1 0.63 (0.46−0.87) / /
 Asia 3 0.68 (0.40−1.16) 0.009 78.8
Cancer-specific survival
 All 14 0.66 (0.54−0.80) 0.000 73.3
Year of publication
 ≥ 2011 6 0.79 (0.65−0.95) 0.011 66.6
 < 2011 8 0.53 (0.37−0.75) 0.003 67.9
Sample size (cases)
 ≥ 500 6 0.74 (0.59−0.93) 0.001 75.3
 < 500 8 0.57 (0.41−0.80) 0.002 68.3
Mean age (years)
 ≥ 65 10 0.75 (0.61−0.93) 0.001 69.1
 < 65 3 0.56 (0.42−0.75) 0.271 23.5
Geographical region
 America 6 0.62 (0.49−0.79) 0.004 70.7
 Europe 3 0.91 (0.62−1.34) 0.016 75.7
 Asia 6 0.49 (0.29−0.84) 0.010 70.1
Recurrence-free survival
 All 9 0.64 (0.50−0.82) 0.000 72.5
Year of publication
 ≥ 2011 5 0.67 (0.47−0.96) 0.000 80.1
 < 2011 4 0.58 (0.37−0.89) 0.029 66.7
Sample size (cases)
 ≥ 500 4 0.65 (0.53−0.80) 0.158 42.3
 < 500 5 0.59 (0.34−1.03) 0.000 82.9
Mean age (years)
 ≥ 65 7 0.63 (0.51−0.78) 0.038 55.0
 < 65 2 0.74 (0.21−2.55) 0.000 93.2
Geographical region
 America 5 0.53 (0.36−0.77) 0.006 72.3
 Europe 1 0.70 (0.56−0.88) / /
 Asia 2 0.59 (0.09−4.06) 0.016 82.7

SRRE: summary relative risk estimate.