Table 2. Summary of meta-analysis results for the numbers of dissected lymph nodes and bladder cancer outcomes.
Analysis specification | Highest category vs. lowest category | |||
---|---|---|---|---|
Studies | SRRE (95% CI) | p−het | I2 | |
Overall survival | ||||
All | 13 | 0.72 (0.64−0.80) | 0.000 | 67.2 |
Year of publication | ||||
≥ 2011 | 9 | 0.75 (0.66−0.84) | 0.000 | 71.7 |
< 2011 | 4 | 0.61 (0.49−0.76) | 0.663 | 0.0 |
Sample size (cases) | ||||
≥ 500 | 8 | 0.74 (0.67−0.83) | 0.003 | 68.0 |
< 500 | 5 | 0.66 (0.48−0.91) | 0.029 | 62.8 |
Mean age (years) | ||||
≥ 65 | 10 | 0.72 (0.64−0.81) | 0.000 | 69.8 |
< 65 | 3 | 0.76 (0.53−1.11) | 0.052 | 66.2 |
Geographical region | ||||
America | 7 | 0.74 (0.69−0.80) | 0.539 | 0.0 |
Europe | 1 | 0.63 (0.46−0.87) | / | / |
Asia | 3 | 0.68 (0.40−1.16) | 0.009 | 78.8 |
Cancer-specific survival | ||||
All | 14 | 0.66 (0.54−0.80) | 0.000 | 73.3 |
Year of publication | ||||
≥ 2011 | 6 | 0.79 (0.65−0.95) | 0.011 | 66.6 |
< 2011 | 8 | 0.53 (0.37−0.75) | 0.003 | 67.9 |
Sample size (cases) | ||||
≥ 500 | 6 | 0.74 (0.59−0.93) | 0.001 | 75.3 |
< 500 | 8 | 0.57 (0.41−0.80) | 0.002 | 68.3 |
Mean age (years) | ||||
≥ 65 | 10 | 0.75 (0.61−0.93) | 0.001 | 69.1 |
< 65 | 3 | 0.56 (0.42−0.75) | 0.271 | 23.5 |
Geographical region | ||||
America | 6 | 0.62 (0.49−0.79) | 0.004 | 70.7 |
Europe | 3 | 0.91 (0.62−1.34) | 0.016 | 75.7 |
Asia | 6 | 0.49 (0.29−0.84) | 0.010 | 70.1 |
Recurrence-free survival | ||||
All | 9 | 0.64 (0.50−0.82) | 0.000 | 72.5 |
Year of publication | ||||
≥ 2011 | 5 | 0.67 (0.47−0.96) | 0.000 | 80.1 |
< 2011 | 4 | 0.58 (0.37−0.89) | 0.029 | 66.7 |
Sample size (cases) | ||||
≥ 500 | 4 | 0.65 (0.53−0.80) | 0.158 | 42.3 |
< 500 | 5 | 0.59 (0.34−1.03) | 0.000 | 82.9 |
Mean age (years) | ||||
≥ 65 | 7 | 0.63 (0.51−0.78) | 0.038 | 55.0 |
< 65 | 2 | 0.74 (0.21−2.55) | 0.000 | 93.2 |
Geographical region | ||||
America | 5 | 0.53 (0.36−0.77) | 0.006 | 72.3 |
Europe | 1 | 0.70 (0.56−0.88) | / | / |
Asia | 2 | 0.59 (0.09−4.06) | 0.016 | 82.7 |
SRRE: summary relative risk estimate.