Table 2. Univariate and multivariate analysis of DFS in 260 ESCC patients.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (years) | ||||||
| ≥ 60 | 1 | 0.940 | NI | |||
| < 60 | 1.012 | 0.736-1.393 | ||||
| Gender | ||||||
| Male | 1 | 0.044* | 1 | 0.554 | ||
| Female | 0.672 | 0.457-0.989 | 1.182 | 0.679-2.056 | ||
| Tumor location | ||||||
| Lower | 1 | 0.894 | NI | |||
| Middle | 0.929 | 0.654-1.318 | ||||
| Upper | 1.019 | 0.541-1.922 | ||||
| Tumor length (cm) | ||||||
| < 5 | 1 | 0.019* | 1 | 0.203 | ||
| ≥ 5 | 1.464 | 1.066-2.012 | 1.179 | 0.848-1.640 | ||
| Differentiation | ||||||
| Well/Moderate | 1 | 0.788 | NI | |||
| Poor/Undifferentiated | 1.053 | 0.724-1.530 | ||||
| Depth of invasion | ||||||
| T1/T2 | 1 | < 0.001* | NI | |||
| T3/T4 | 2.147 | 1.438-3.205 | ||||
| Lymph node involvement | ||||||
| Negative | 1 | < 0.001* | NI | |||
| Positive | 2.854 | 2.056-3.962 | ||||
| TNM stage | ||||||
| I/II | 1 | < 0.001* | 1 | < 0.001* | ||
| III | 2.439 | 1.766-3.368 | 2.209 | 1.577-3.095 | ||
| Smoking | ||||||
| Never | 1 | 0.002* | 1 | 0.033* | ||
| Ever | 1.734 | 1.229-2.448 | 1.755 | 1.047-2.942 | ||
| Alcohol consumption | ||||||
| Never | 1 | 0.019* | 1 | 0.758 | ||
| Ever | 1.476 | 1.065-2.044 | 0.941 | 0.638-1.387 | ||
| mGPS | ||||||
| 0 | 1 | 0.123 | NI | |||
| 1/2 | 1.360 | 0.920-2.008 | ||||
| FC score | ||||||
| 0 | 1 | 0.003* | 1 | 0.028* | ||
| 1/2 | 1.650 | 1.181-2.303 | 1.468 | 1.043-2.067 | ||
DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; NI, not included.
*
P < 0.05.