Table 3. Univariate and multivariate analysis of OS in 260 ESCC patients.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (years) | ||||||
| ≥ 60 | 1 | 0.450 | NI | |||
| < 60 | 1.136 | 0.816-1.582 | ||||
| Gender | ||||||
| Male | 1 | 0.060 | NI | |||
| Female | 0.681 | 0.457-1.016 | ||||
| Tumor location | ||||||
| Lower | 1 | 0.876 | NI | |||
| Middle | 0.933 | 0.646-1.368 | ||||
| Upper | 1.069 | 0.550-2.076 | ||||
| Tumor length (cm) | ||||||
| < 5 | 1 | 0.081 | NI | |||
| ≥ 5 | 1.344 | 0.965-1.873 | ||||
| Differentiation | ||||||
| Well/Moderate | 1 | 0.791 | NI | |||
| Poor/Undifferentiated | 1.054 | 0.716-1.550 | ||||
| Depth of invasion | ||||||
| T1/T2 | 1 | < 0.001* | NI | |||
| T3/T4 | 2.254 | 1.471-3.455 | ||||
| Lymph node involvement | ||||||
| Negative | 1 | < 0.001* | NI | |||
| Positive | 2.799 | 1.989-3.938 | ||||
| TNM stage | ||||||
| I/II | 1 | < 0.001* | 1 | < 0.001* | ||
| III | 2.319 | 1.658-3.242 | 2.150 | 1.523-3.034 | ||
| Smoking | ||||||
| Never | 1 | 0.004* | 1 | 0.084 | ||
| Ever | 1.683 | 1.178-2.407 | 1.445 | 0.952-2.192 | ||
| Alcohol consumption | ||||||
| Never | 1 | 0.007* | 1 | 0.818 | ||
| Ever | 1.597 | 1.139-2.240 | 1.049 | 0.698-1.577 | ||
| mGPS | ||||||
| 0 | 1 | 0.042* | 1 | 0.341 | ||
| 1/2 | 1.514 | 1.016-2.257 | 0.760 | 0.432-1.337 | ||
| FC score | ||||||
| 0 | 1 | < 0.001* | 1 | 0.004* | ||
| 1/2 | 1.879 | 1.333-2.648 | 2.070 | 1.266-3.385 | ||
OS, overall survival.
*
P < 0.05.