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. 2016 Aug 19;7(38):61544–61561. doi: 10.18632/oncotarget.11399

Figure 4. Gene expression analysis and correlation reveals two classes of PP2A subunits.

Figure 4

(A) Circos plot for each of the 17 PP2A subunits analyzed in 19 cancer types. Starting from the inner most ring, each subunit was analyzed for gene expression, methylation, mutations, deep deletions, and amplifications. The outermost ring shows the cancer type for analysis. The abbreviation of each cancer is represented as described in the TCGA portal. (B) Representative correlation clustergrams of the PP2A subunits derived from analysis of 19 cancer types. Two distinct classes of PP2A subunits whose expression negatively correlates emerge, highlighted in green. The subunits highlighted in green, PPP2R1A, PPP2R2D, PPP2R3B, PPP2R5B, and PPP2R5D are referred to as Class I. Negative correlations are shown as blue and positive correlations red as represented by the scale. The abbreviation of each cancer is represented as described in the TCGA portal. (C) A table listing the two groups of PP2A subunits identified from the clustergram in (B).