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. 2016 Aug 11;7(38):61630–61642. doi: 10.18632/oncotarget.11210

Figure 3. p53 mutants enhance TLR3 induced immune responses.

Figure 3

A. mRNA expression of TLR3, IL-8, IFN-β and IL-6 was analyzed in HCT116 p53−/− cells that were first transfected with WT or mutant p53 for 24 h and then exposed (black bars) or not (gray bars) for 3 h to the TLR3 ligand poly(I:C) (5μg/mL). B. Secretion of IL-6 after ligand treatment in cells transfected with WT or mutant p53 mutant as measured by ELISA. Data presented are means and standard deviations from triplicate determinations from 3 independent experiments. * p<0.001.