Table 2. Multivariate Cox proportional hazard models for prediction of ESRD in different cohorts of patients who received and did not receive nephrouretectomies or AA.

	N of subjects	N of ESRD	Person-years	Rate1	Age, sex-adjusted HR (95% CI)	Model 1a	Model 2
All
Comparison Group	208136	1829	997339	1.83	1.00	1.00	1.00
UC (Total)	26017	979	98929	9.90	5.46 (5.05–5.91)***	3.87 (3.57–4.19)***
Without Nephrouretectomy	21163	553	82887	6.67	3.72 (3.38-4.09)***	2.74 (2.48-3.01)***	2.76b (2.51-3.04)***
With Nephrouretectomy	4854	426	16042	26.56	13.8 (12.4-15.4)***	8.88 (7.95-9.93)***
Without AA	21694	771	82188	9.38	5.19 (4.77-5.64)***	3.69 (3.38-4.02)***	3.18c (2.92-3.46)***
With AA	4323	208	16740	12.43	6.78 (5.87-7.82)***	4.73 (4.09-5.46)***
UT-UC	4263	330	12515	16.37	13.5 (11.9–15.2)***	7.75 (6.84–8.78)***
Without Nephrouretectomy	957	73	2221	32.87	16.6 (13.1-21.0)***	7.07 (5.55-9.01)***	3.20b (2.65-3.86)***
With Nephrouretectomy	3306	257	10294	24.97	13.0 (11.4-14.8)***	8.25 (7.20-9.45)***
Without AA	3326	250	9741	25.66	13.1 (11.5-15.0)***	7.75 (6.75-8.89)***	6.06c (5.32-6.91)***
With AA	937	80	2774	28.84	14.6 (11.7-18.4)***	7.80 (6.20-9.82)***
B-UC	21537	642	85750	7.49	4.18 (3.82–4.57)***	3.12 (2.84–3.42)***
Without Nephrouretectomy	20029	475	80137	5.93	3.31 (2.99-3.66)***	2.50 (2.26-2.77)***	2.72b (2.47-3.00)***
With Nephrouretectomy	1508	167	5613	29.75	15.9 (13.6-18.6)***	10.6 (8.99-12.4)***
Without AA	18184	516	71919	7.17	4.00 (3.62-4.41)***	2.97 (2.69-3.28)***	2.63c (2.39-2.90)***
With AA	3353	126	13831	9.11	5.11 (4.26-6.12)***	3.89 (3.24-4.66)***

¹Rate per 1000 person-years

ESRD: end-stage renal disease, HR: hazard ratio.

^aMultivariate model adjusted for age, sex, geographic region, occupation, monthly income, and comorbidities (diabetes, hypertension, coronary heart disease, atrial fibrillation, heart failure, chronic kidney disease, and hyperlipidemia).

^bAdd adjusted for nephrouretectomy in model 1.

^cAdd adjusted for AA in model 1.