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A. Histones (50 μg/ml) induce phosphorylation of ERK and IκB in Hepa1-6 cells. B-D. The MEK inhibitor PD98059 (20 μM) inhibited the phosphorylation of ERK and IκB (B) and the nuclear translocation of p65 in Hepa1-6 cells following histone treatment (50 μg/ml, 60 min).
