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. 2016 Aug 11;7(38):61728–61740. doi: 10.18632/oncotarget.11226

Figure 4. Activation of the MAPK/ERK-NF-κB pathway contributes to histone-induced HCC cell migration and invasion.

Figure 4

A. Both MEK (PD98059, 20 μM) and NF-κB (Bay11-7082, 10 μM) inhibitors suppressed histone (50 μg/ml, 24 hours)-induced Hepa1-6 cell migration A. and invasion B. (n=3, *, p<0.05). C-F. Knockdown of p65 and MEK by RNAi inhibited histone (50 μg/ml, 24 hours)-induced HCC cell migration (C, D) and invasion (E, F) (n=3, *, p<0.05, versus control group).