Figure 5. TLR4 is required for histone-induced NF-κB activation and HCC cell migration.
Knockdown of TLR4 (but not TLR2 and RAGE) by RNAi A. inhibited histone (50 μg/ml)-induced Hepa1-6 cell migration B, C. phosphorylation of ERK and IκB D. and cell invasion E. (n=3, *, p<0.05).