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. 2016 Aug 20;7(38):61860–61873. doi: 10.18632/oncotarget.11452

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Copyright: © 2016 Tzaridis et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Gene expression profiling after high-dose (100 nM) and low-dose (5 nM) Actinomycin-D treatment of ependymoma cell lines, EP1NS (ST-EPN-RELA) and SJ-BT57 (PF-EPN-A). Unsupervised hierarchical clustering of top 300 differentially expressed genes revealed distinct transcriptome influences according to treatment. (B) Ingenuity pathway analysis of significant differentially regulated genes between high-dose (100 nM) and low-dose (5 nM) treatment of the cell lines pinpointed the p53 pathway as one of the top ten upregulated pathways after low-dose treatment.