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. 2016 Aug 16;7(38):61874–61889. doi: 10.18632/oncotarget.11297

Figure 2. Nucks1 is haplo-insufficient in suppressing IR-induced TL.

Figure 2

a. Agarose gels to show the results from semi-quantitative PCR analysis to detect LOH at Trp53 and Nucks1. Genomic DNAs from tail and TL of the same mouse were used as template. Arrows indicate LOH of the Nucks1 wild type and knockout alleles. M: molecular weight marker; W: wild type allele; K: knockout allele; WT CTRL: tail and thymus of a sham-irradiated 129S1/SvImJ mouse. b. Results from TaqMan qRT-PCR assays to assess Trp53 expression in normal thymi of Trp53+/−, wild type (WT) and Nucks1+/− mice, and in IR-induced TLs of Trp53+/− and Trp53+/−Nucks1+/− mice.