Table 1. Tumor types and frequencies in Trp53+/− and Trp53+/− Nucks1+/− mice.
| Tumor type1 | Tumor frequency (%) | |
|---|---|---|
| Trp53+/− | Trp53+/− Nucks1+/− | |
| Thymic lymphoma | 38.7 | 66.7 |
| Splenic lymphoma | 12.9 | 7.4 |
| Sarcoma | 16.7 | 22.2 |
| Lung tumor2 | - | 11.1 |
| Other tumors | 16.7 | 14.8 |
| Paralysis3 | 22.6 | 11.1 |
1
Only primary tumors, as examined by H&E or immunohistochemistry.
2
Epithelial-origin lung tumors were found in Trp53+/− Nucks1+/− mice only.
3
Mice were characterized as succumbing to paralysis when their limbs, usually their hind limbs, lost motility followed by severe weight loss.