Table 3. Genotypes significantly associated with increased relative risk to develop osteosarcoma compared to healthy controls identified by logistic regression analysis.
| Polymorphism [risk-associated genotype] | OR (CI 95%) | p |
|---|---|---|
| ABCC2_1249A/G [HET + VAR] | 1.71 (1.20–2.43) | 0.003 |
| ABCC2_3972A/G [VAR] | 2.24 (1.18–4.24) | 0.013 |
| hMLH1_676A/G [HET + VAR] | 1.62 (1.14–2.31) | 0.007 |
| XPG_3508G/C [VAR] | 2.47 (1.36–4.50) | 0.003 |
| GGH_401T/C [VAR] | 2.14 (1.07–4.69) | 0.032 |
| GGH_16T/C [VAR] | 2.24 (1.07–4.69) | 0.033 |
| MTHFR_677T/C [VAR] | 1.68 (1.08–2.61) | 0.022 |
| TYMS_28bp_VNTR [HET + VAR] | 1.67 (1.18–2.35) | 0.004 |
| MDM2_309T/G [HET + VAR] | 1.73 (1.22–2.46) | 0.002 |
| [VAR] | 2.25 (1.46–3.47) | < 0.001 |
| TP53_IVS2 + 38G/C [HET + VAR] | 13.37 (7.76–23.03) | < 0.0001 |
| [VAR] | 15.63 (10.20–24.39) | < 0.0001 |
| TP53_ex4 + 119G/C [WT] | 1.68 (1.17–2.41) | 0.005 |
OR, odd ratio; CI, confidence interval; p values refer to the genotype with higher risk which is given in brackets; WT, wild-type; HET, heterozygous; VAR, variant.