Table 5. Genotype frequencies in the subgroups of osteosarcoma patients eligible for survival (survival cohort) and toxicity (toxicity cohort) analyses.

Main gene function	Polymorphism	Survival cohort (n = 126 patients)			Toxicity cohort (n = 57 patients)
		WT (%)	HET (%)	VAR (%)	WT (%)	HET (%)	VAR (%)
TRANSPORT	ABCB1_3435T/C	29	44	27	33	44	23
	ABCB1_1236T/C	31	46	23	29	51	20
	ABCB1_2677G/T/A	27	46	27	21	49	30
	ABCC2_1249A/G	49	48	3	54	44	2
	ABCC2_-24A/G	59	37	4	57	39	4
	ABCC2_3972A/G	48	35	17	37	41	22
	ABCG2_34A/G	85	15	0	91	9	0
	ABCG2_421A/C	82	16	2	85	15	0
	RFC_80A/G	37	46	17	37	51	12
DNA REPAIR	APE1_2197T/G	18	47	35	16	52	32
	ERCC1_8092T/G	60	34	6	60	38	2
	ERCC1_19007T/C	30	46	24	26	56	18
	hMLH1_676A/G	37	51	12	36	51	13
	hMSH2_IVS12-6T/C	89	11	0	89	11	0
	hOGG1_1245C/G	64	28	8	68	25	7
	XPD_35931T/G	38	49	13	37	52	11
	XPD_23591A/G	40	47	13	39	52	9
	XPG_3508G/C	57	31	12	65	30	5
	XRCC1_28152A/G	42	46	12	35	49	16
	XRCC3_18067T/C	30	55	15	27	58	15
FOLATE CYCLE	DHFR_Ins/Del	38	46	16	30	52	18
	FOLR1_181delC	94	6	0	98	2	0
	GGH_452T/C	82	15	3	83	12	5
	GGH_401T/C	49	35	16	55	29	16
	GGH_16T/C	61	24	15	66	19	15
	MTHFD1_1958T/C	28	55	17	27	57	16
	MTHFR_677T/C	31	52	17	33	51	16
	MTHFR_1298A/C	41	49	10	39	50	11
	SHMT_1420T/C	53	40	7	50	41	9
	TYMS_28bp_VNTR	39	43	18	30	47	23
	TYMS_1494del6	33	53	14	30	54	16
APOPTOSIS	ATM_40C/G	98	2	0	98	2	0
	ATM_61A/G	72	26	2	73	25	2
	MDM2_309T/G	30	50	20	28	47	25
	p21_98A/C	87	13	0	93	7	0
	TP53_PIN3_IVS3 + 16 bp	66	29	5	63	35	2
	TP53_IVS2+38G/C	7	35	58	9	34	57
	TP53_ex4 + 119G/C	66	27	7	70	21	9
DRUG METABOLISM	GSTT1_gen_null	83	0	17	88	0	12
	GSTM1_gen_null	42	0	58	39	0	61
	GSTP1_313A/G	52	42	6	54	44	2
	CYP2C19*2_681A/G	75	24	1	72	26	2
	CYP2B6*6	65	29	6	68	25	7
	CYP2B6*7	99	1	0	100	0	0
	CYP2C9*2_430T/C	73	26	1	68	32	0
	CYP2C9*3_1075A/C	86	11	3	91	9	0
	CYP3A4*1B_-392A/G	90	10	0	89	11	0

WT, wild-type; HET, heterozygous; VAR, variant.