Table 6. Toxic events associated with genotypes in 57 osteosarcoma patients and relative risk estimation by logistic regression analyses.
| Toxic events | Frequency of toxic events | Polymorphism | p (Fisher's Test) | Univariate logistic regression | Multivariate logistic regression | ||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | Adjusted OR (95% CI) | p | ||||
| Leukopenia grade 4 | 79% | ABCC2_1249A/G [HET + VAR] MTHFR_1298A/C [HET + VAR] |
0.007 0.047 |
13.16 (1.56–111.12) 4.15 (1.06–16.13) |
0.018 0.040 |
10.20 (1.17–90.90) 2.93 (0.69–12.50) |
0.035 0.145 |
| Thrombocytopenia grade 4 | 68% | ABCC2_1249A/G [HET + VAR] XPD_23591A/G [HET + VAR] |
0.024 0.004 |
4.33 (1.20–15.63) 5.59 (1.66–18.87) |
0.025 0.006 |
23.81 (2.50–250.00) 27.78 (3.10–250.00) |
0.006 0.003 |
| Red blood cells transfusion | 54% | ABCC2_1249A/G [HET + VAR] | 0.002 | 6.06 (1.88–19.60) | 0.003 | ||
| Platelet transfusion | 39% | ABCC2_1249A/G [HET + VAR] | 0.030 | 3.36 (1.10–10.20) | 0.033 | ||
| Fever | 70% | ERCC1_8092T/G [HET + VAR] | 0.016 | 6.49 (1.30–32.26) | 0.023 | ||
| Nausea/Vomiting | 44% | ABCC2_3972A/G [WT] XRCC3_18067T/C [HET + VAR] |
0.001 0.037 |
8.33 (2.35–29.58) 4.42 (1.08–18.18) |
0.001 0.039 |
5.85 (1.57–21.85) 3.22 (0.56–18.52) |
0.009 0.188 |
| Hepatotoxicity (Transaminases grade 4) | 56% | ABCB1_1236T/C [HET + VAR] ABCC2_1249A/G [WT] GGH_16T/C [WT] |
0.047 0.050 0.025 |
2.06 (1.16–3.66) 1.96 (1.20–3.20) 2.87 (1.53–5.41) |
0.014 0.007 0.001 |
2.28 (1.23–4.26) 1.83 (1.10–3.05) 2.95 (1.56–5.59) |
0.009 0.021 0.001 |
OR, odd ratio; CI, confidence intervals; WT, wild-type; HET + VAR, heterozygous + variant; p values refer to the genotype with higher risk which is given in brackets.