Table 7. Toxic events significantly associated with genotypes in relation to methotrexate or doxorubicin, cisplatin and ifosfamide by logistic regression analyses.
| Drug (cycles) | Toxic events | Polymorphism | Univariate logistic regression | Multivariate logistic regression | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | p | Adjusted OR (95% CI) | p | |||
| Methotrexate (n = 520) | Nausea/Vomiting | ABCC2_3972A/G [WT] | 3.15 (1.06–9.37) | 0.039 | ||
| Hepatotoxicity (Transaminases grade 4) | ABCB1_1236T/C [HET + VAR] ABCC2_1249A/G [WT] GGH_16T/C [WT] |
2.21 (1.22–4.00) 2.48 (1.47–4.18) 2.93 (1.53–5.62) |
0.009 0.001 0.001 |
2.46 (1.29–4.72) 2.28 (1.31–3.96) 3.05 (1.57–5. 92) |
0.001 0.004 0.001 |
|
| Doxorubicin/ Cisplatin/ Ifosfamide (n = 488) | Leukopenia grade 4 | ABCC2_1249A/G [HET + VAR] MTHFR_1298A/C [HET + VAR] |
2.80 (1.63–4.83) 2.19 (1.26–3.82) |
< 0.001 0.006 |
2.19 (1.23–3.92) 1.75 (0.97–3.13) |
0.008 0.063 |
| Thrombocytopenia grade 4 Red blood cells transfusion Platelet transfusion Nausea/Vomiting |
ABCC2_1249A/G [HET + VAR] ABCC2_1249A/G [HET + VAR] ABCC2_1249A/G [HET + VAR] ABCC2_3972A/G [WT] |
4.35 (2.17–8.77) 2.13 (1.12–4.07) 3.55 (1.59–7.87) 2.28 (1.02–5.07) |
< 0.0001 0.022 0.002 0.045 |
|||
OR, Odd ratio; CI: confidence interval; p values refer to the genotype with higher risk which is given in brackets; WT, wild-type; HET + VAR, heterozygous + variant.