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. 2016 Aug 19;7(38):62049–62069. doi: 10.18632/oncotarget.11384

Table 3. Clinicopathological features of patients tested by quantitative PCR in this study.

Clinicopathological Features CD54 Lgr5 CD133 Oct4 EpCAM Sox2
Low High Low High Low High Low High Low High Low High
n=53 n=40 p value n=50 n=43 p value n=69 n=24 p value n=44 n=49 p value n=65 n=28 p value n=43 n=50 p value
(%) (%) (%) (%) (%) (%) (%) (%) (%) (%) (%) (%)
Age (years)
 Mean 59.4 61.1 58.6 62.0 61.2 57.1 61.6 58.9 60.0 60.5 63.6 57.2
 SD 12.7 10.6 0.498 11.9 11.5 0.160 11.8 11.7 0.140 10.5 12.9 0.287 12.0 11.6 0.857 9.5 12.9 0.010
 ≤60 26 (49) 18 (45) 0.698 25 (50) 19 (44) 0.576 31 (45) 13 (54) 0.435 18 (41) 26 (53) 0.241 32 (49) 12 (43) 0.572 14 (33) 30 (60) 0.008
 >60 27 (51) 22 (55) 25 (50) 24 (56) 38 (55) 11 (46) 26 (59) 23 (47) 33 (51) 16 (57) 29 (67) 20 (40)
Gender 0.543 0.253 1.000 0.3 0.335 0.357
 Male 41 (77) 33 (83) 42 (84) 32 (74) 55 (80) 19 (79) 33 (75) 41 (84) 50 (77) 24 (86) 36 (84) 38 (76)
 Female 12 (23) 7 (18) 8 (16) 11 (26) 14 (20) 5 (21) 11 (25) 8 (16) 15 (23) 4 (14) 7 (16) 12 (24)
Longitudinal location 0.672 0.984 0.250 0.984 0.657 0.095
 U 19 (36) 18 (45) 19 (38) 18 (42) 29 (42) 8 (33) 17 (39) 20 (41) 26 (40) 11 (39) 14 (33) 23 (46)
 M 7 (13) 7 (18) 8 (16) 6 (14) 9 (13) 5 (21) 7 (16) 7 (14) 8 (12) 6 (21) 6 (14) 8 (16)
 L 25 (47) 14 (35) 21 (42) 18 (42) 30 (43) 9 (38) 19 (43) 20 (41) 29 (45) 10 (36) 23 (53) 16 (32)
 UML 2 (4) 1 (3) 2 (4) 1 (2) 1 (1) 2 (8) 1 (2) 2 (4) 2 (3) 1 (4) 0 (0) 3 (6)
Cross sectional location 0.082 0.280 0.886 0.412 0.157 0.933
 Lesser 25 (47) 14 (35) 21 (42) 18 (42) 27 (39) 12 (50) 17 (39) 22 (45) 22 (34) 17 (61) 17 (40) 22 (44)
 Greater 3 (6) 7 (18) 4 (8) 6 (14) 8 (12) 2 (8) 4 (9) 6 (12) 9 (14) 1 (4) 4 (9) 6 (12)
 Anterior 3 (6) 0 (0) 1 (2) 2 (5) 3 (4) 0 (0) 0 (0) 3 (6) 3 (5) 0 (0) 2 (5) 1 (2)
 Posterior 8 (15) 3 (8) 9 (18) 2 (5) 8 (12) 3 (13) 6 (14) 5 (10) 9 (14) 2 (7) 5 (12) 6 (12)
 Multiple 14 (26) 16 (40) 15 (30) 15 (35) 23 (33) 17 (71) 17 (39) 13 (27) 22 (34) 8 (29) 15 (35) 15 (30)
Macroscopic type 0.569 0.547 0.567 0.681 0.104 0.149
 I-II 23 (43) 15 (38) 19 (38) 19 (44) 27 (39) 11 (46) 17 (39) 21 (43) 23 (35) 15 (54) 21 (49) 17 (34)
 III-IV 30 (57) 25 (63) 31 (62) 24 (56) 42 (61) 13 (54) 27 (61) 28 (57) 42 (65) 13 (46) 22 (51) 33 (66)
Differentiation 0.569 0.067 0.052 0.335 0.174 0.513
 Well/Moderately 6 (11) 7 (18) 3 (6) 10 (23) 12 (17) 1 (4) 7 (16) 6 (12) 8 (12) 5 (18) 7 (16) 6 (12)
 Moderately-poorly 5 (9) 3 (8) 5 (10) 3 (7) 7 (10) 1 (4) 5 (11) 3 (6) 4 (6) 4 (14) 4 (9) 4 (8)
 Poorly 42 (79) 30 (75) 42 (84) 30 (70) 50 (72) 22 (92) 32 (73) 40 (82) 53 (82) 19 (68) 32 (74) 40 (80)
Tumor size (cm)
 Mean±SD 7.4±2.5 7.1±2.8 0.630 7.3±2.7 7.3±2.5 0.989 7.3±2.6 7.1±2.8 0.730 7.3±2.5 7.2±2.7 0.911 7.6±2.8 6.4±1.8 0.085 6.9±1.9 7.6±3.1 0.510
 ≤7 31 (58) 27 (68) 0.344 32 (64) 26 (60) 0.879 42 (61) 16 (67) 0.614 26 (59) 32 (65) 0.898 37 (57) 21 (75) 0.099 28 (65) 30 (60) 0.614
 >7 22 (42) 13 (33) 18 (36) 17 (40) 27 (39) 8 (33) 18 (41) 17 (35) 28 (43) 7 (25) 15 (35) 20 (40)
Vessels/nerves invasion 0.907 0.255 0.440 0.394 0.810 0.794
 Negative 39 (74) 29 (73) 39 (78) 29 (67) 49 (71) 19 (79) 34 (77) 34 (69) 48 (74) 20 (71) 32 (74) 36 (72)
 Positive 14 (26) 11 (28) 11 (22) 14 (33) 20 (29) 5 (21) 10 (23) 15 (31) 17 (26) 8 (29) 11 (26) 14 (28)
T stage 0.993 0.549 0.107 0.035 0.072 0.030
 1-2 4 (8) 3 (8) 3 (6) 4 (9) 7 (10) 0 (0) 6 (14) 1 (2) 7 (11) 0 (0) 6 (14) 1 (2)
 3-4 49 (92) 37 (93) 47 (94) 39 (91) 62 (90) 24 (100) 38 (86) 48 (98) 58 (89) 28 (100) 37 (86) 49 (98)
N stage 0.760 0.405 0.282 0.657 0.900 0.726
 0 5 (9) 5 (13) 5 (10) 5 (12) 7 (10) 3 (13) 4 (9) 6 (12) 6 (9) 4 (14) 5 (12) 5 (10)
 1 6 (11) 5 (13) 5 (10) 6 (14) 10 (14) 1 (4) 4 (9) 7 (14) 10 (15) 1 (4) 7 (16) 4 (8)
 2 12 (23) 8 (20) 10 (20) 10 (23) 16 (23) 4 (17) 11 (25) 9 (18) 12 (18) 8 (29) 7 (16) 13 (26)
 3 30 (57) 22 (55) 30 (60) 22 (51) 36 (52) 16 (67) 25 (57) 27 (55) 37 (57) 15 (54) 24 (56) 28 (56)
M stage 0.380 0.971 0.934 0.285 0.006 0.276
 0 46 (87) 32 (80) 42 (84) 36 (84) 58 (84) 20 (83) 35 (80) 43 (88) 50 (77) 28 (100) 38 (88) 40 (80)
 1 7 (13) 8 (20) 8 (16) 7 (16) 11 (16) 4 (17) 9 (20) 6 (12) 15 (23) 0 (0) 5 (12) 10 (20)
TNM stage 0.249 0.377 0.288 0.828 0.445 0.761
 I-II 6 (11) 8 (20) 6 (12) 8 (19) 12 (17) 2 (8) 7 (16) 7 (14) 11 (17) 3 (11) 7 (16) 7 (14)
 III-IV 47 (89) 32 (80) 44 (88) 35 (81) 57 (83) 22 (92) 37 (84) 42 (86) 54 (83) 25 (89) 36 (84) 43 (86)
Chemotherapy 0.835 0.713 0.963 0.164 0.981 0.105
 No 38 (53) 22 (55) 26 (52) 24 (56) 37 (54) 13 (54) 27 (61) 23 (47) 35 (54) 15 (54) 27 (63) 23 (46)
 Yes 25 (47) 18 (45) 24 (48) 19 (44) 32 (46) 11 (46) 17 (39) 26 (53) 30 (46) 13 (46) 16 (37) 27 (54)