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. 2016 Aug 19;7(38):62070–62083. doi: 10.18632/oncotarget.11386

Figure 2. MMP-13 is involved in TNF-α increasing cell migration in lung cancer cells.

Figure 2

NCI-H446 cells were pretreated with MMPs inhibitors NOB (64 μM), HYD (50 μM), SB-3CT (10 μM), NNGH (10 μM), UK-356618 (73 nM) a. or MMP-13 silencing b. prior to TNF-α (2 ng/ml) stimulation. Cell migration was determined by Transwell migration assay. Data are presented as the mean±SEM, n=3. ***p<0.001, One-way ANOVA with post Newman-Keuls test. One representative from three experiments is shown. NOB: Nobiletin; HYD: N-CBZ-Pro-Leu-Gly hydroxamate.