Figure 4. ATM mediate TNF-α inducing ERK/p38-NF-κB activation in lung cancer cells.

Cells were conferred ATM silencing a-c, e. or CGK733 treatment d, f. prior to TNF-α (2 ng/ml) stimulation and the phosphorylation of ERK, p38 or p65 was investigated by confocal fluorescence microscope (a-c) or western blot (d-f). One representative from three experiments is shown. CGK: CGK733. The immunoblots were cropped to improve the clarity and conciseness of the presentation.