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. 2016 Aug 19;7(38):62208–62223. doi: 10.18632/oncotarget.11403

Figure 4. Restoration of let-7e inhibited cell proliferation, migration and invasion and facilitated apoptosis of GSCs.

Figure 4

A. The CCK-8 assay was employed to determine the effect of let-7e on GSC proliferation. B. Quantification of GSC migration and invasion in groups according to let-7e expression. Representative images and accompanying statistical plots are presented. C. 3D Spheroid-based tumor migration assays of the effect let-7e expression on GSC migration. Scale bars, 60 μm. D. Flow cytometry analysis of GSCs in groups according to let-7e expression. Data are presented as the mean ± SD (n=5, each group). *P<0.05 vs. pre-NC group; #P<0.05 vs. anti-NC group. Scale bars, 20 μm.