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. 2016 Aug 19;7(38):62292–62304. doi: 10.18632/oncotarget.11410

Figure 2. Elevated XPO5 mRNA expression and stability in malignant melanoma.

Figure 2

A. qRT-PCRs showed an increase in expression of XPO5 mRNA during melanoma progression in primary and metastatic melanoma tissues (n=4) and cell lines (n=13) compared with NHEMs (n=15). B. XPO5 mRNA expression decreased after treatment with the MEK inhibitors PD98059 and U0126 in comparison to DMSO-treated cells (n=10). C. The stability of XPO5 mRNA was determined by qRT-PCR after treatment of NHEMs and melanoma cell lines (MM) with alpha-amanitin for 0, 16 and 24 hours. The remaining XPO5 mRNA level in the melanoma cell lines (solid line) was significantly different to that of the NHEMs (dashed line) after the 24 h treatment (n=3). D. The relative distribution of the rs11077 genotypes in melanoma patients (n=20) versus the healthy control group (n-21). In the control group, the values are equivalent to the distribution in the Caucasian population. In melanoma patients, half of the patients had the C/C variant SNP (50%). E. Relative XPO5 mRNA expression compared to NHEM in the homozygous rs11077 genotypes A/A and C/C.