Table 2. Distribution of HPV genotypes by sociodemographic, cytological and histologic diagnosis.
| Characteristic | HPV (n, %) | HPV16 (n, %) | HPV58 (n, %) | Infection with single HPV type (n, %) | Co-infection with multiple types (n, %) | |
|---|---|---|---|---|---|---|
| HPV positive | HPV negative | |||||
| Marital | ||||||
| Married | 385(15.3) | 2125(84.7) | 48(1.9) | 32(1.3) | 246(63.9) | 139(36.1) |
| Single/divorced | 47(22.7) | 160(77.3) | 7(3.4) | 3(1.4) | 24(51.1) | 23(48.9) |
| χ2 | 7.761 | 2.082 | 0.046 | 2.943 | ||
| P value | 0.005 | 0.149 | 0.831 | 0.086 | ||
| Age of first sexual intercourse | ||||||
| ≤16 | 1 (7.7) | 12(92.3) | 0(0.0) | 0(0.0) | 1(100) | 0(0.0) |
| 17 ~ 20 | 106(18.2) | 475(81.8) | 15(2.6) | 7(1.2) | 64(60.4) | 42(39.6) |
| ≥21 | 279(14.3) | 1678(85.7) | 34(1.7) | 24(1.2) | 180(64.5) | 99(35.5) |
| χ2 | 6.111 | 1.951 | 0.162 | 1.145 | ||
| P value | 0.047 | 0.377 | 0.922 | 0.564 | ||
| Age of primiparity | ||||||
| ≤20 | 20(13.0) | 134(87.0) | 3(1.9) | 2(1.3) | 15(75.0) | 5(25.0) |
| 21~25 | 193(15.7) | 1035(84.3) | 22(1.8) | 10(0.8) | 121(62.7) | 72(37.3) |
| 26~30 | 122(13.4) | 789(86.6) | 13(1.4) | 13(1.4) | 77(63.1) | 45(36.9) |
| ≥31 | 27(13.6) | 171(86.4) | 3(1.5) | 4(2.0) | 20(74.1) | 7(25.9) |
| χ2 | 2.765 | 0.538 | 3.138 | 2.414 | ||
| P value | 0.429 | 0.910 | 0.371 | 0.491 | ||
| Parity | ||||||
| Nullipara | 11(15.9) | 58(84.1) | 1(1.4) | 1(1.4) | 5(45.5) | 6(54.4) |
| Multipara | 367(14.8) | 2105(85.2) | 45(1.8) | 29(1.2) | 236(64.3) | 131(35.7) |
| χ2 | 0.064 | 0.052 | 0.044 | 1.642 | ||
| P value | 0.801 | 0.820 | 0.834 | 0.200 | ||
| Contraceptive measures | ||||||
| Oral contraceptive | 14(18.9) | 60(81.1) | 2(2.7) | 1(1.4) | 10(71.4) | 4(28.6) |
| Other contraceptive measures | 418(15.8) | 2225(84.2) | 53(2.0) | 34(1.3) | 260(62.2) | 158(37.8) |
| χ2 | 0.519 | 0.177 | 0.002 | 0.492 | ||
| P value | 0.471 | 0.674 | 0.961 | 0.483 | ||
| Medical insurance | ||||||
| Yes | 302(14.9) | 1721(85.1) | 38(1.9) | 27(1.3) | 189(62.6) | 113(37.4) |
| No | 130(18.7) | 564(81.3) | 17(2.4) | 8(1.2) | 81(62.3) | 49(37.7) |
| χ2 | 5.591 | 0.850 | 0.134 | 0.003 | ||
| P value | 0.018 | 0.357 | 0.714 | 0.957 | ||
| Cytological | ||||||
| NILM | 285(25.3) | 842(74.7) | 33(2.9) | 20(1.8) | 179(62.8) | 106(37.2) |
| ASCUS+ | 48(75.0) | 16(25.0) | 11(17.2) | 7(10.9) | 21(43.8) | 27(56.2) |
| χ2 | 74.302 | 34.610 | 22.949 | 6.220 | ||
| P value | <0.001 | <0.001 | <0.001 | 0.013 | ||
| Histological diagnosis | ||||||
| NILM | 184(23.1) | 613(76.9) | 12(1.5) | 9(1.1) | 105(57.1) | 79(42.9) |
| CIN1 | 83((87.4) | 12(12.6) | 14(14.7) | 9(9.5) | 59(71.1) | 24(28.9) |
| CIN2+ | 28(93.3) | 2(6.7) | 11(36.7) | 4(13.3) | 13(46.4) | 15(53.6) |
| χ2 | 214.819/194.228* | 124.413/121.720* | 41.330/40.160* | 7.058 | ||
| P value | <0.001/<0.001* | <0.001/<0.001* | <0.001/<0.001* | 0.029 | ||
HPV 16 and HPV 58 were both among the five most prevalent HPV types (HPV52, 16, 53, 51, and 58) and the five most risk HPV types (HPV33, 16, 58, 56, and 68) in Shenzhen. Therefore, we explored the relationship between the distribution of HPV16 and HPV58 and sociodemographic, cytological, and histologic diagnosis in Table 2.
HPV: Human papillomavirus; NILM: No intraepithelial lesion or malignant cells; ASCUS: Atypical squamous cells of undermined significance; CIN: Cervical intraepithelial neoplasia
*
Linear-by-Linear test