Table 3. Different triage strategies for high-risk HPV positive women.
| Triage strategy | HPV positive women | |||
|---|---|---|---|---|
| Endpoint CIN2+ | ||||
| NPV (95%CI),% | PPV (95%CI),% | Sensitivity (95%CI),% | Specificity (95%CI),% | |
| Cytology | 95.9(92.5,98.0) | 39.1(25.0,53.2) | 64.3(46.5,82.0) | 89.2(84.8,92.7) |
| HPV16 | 93.8(90.1,96.4) | 32.4(18.0,49.8) | 42.9(24.5,62.8) | 90.6(86.5,93.9) |
| HPV16/58 | 94.5(90.8,97.1) | 25.9(15.3,39.0) | 53.6(33.9,72.5) | 83.9(78.9,88.1) |
| HPV16/33 | 95.5(92.1,97.7) | 33.3(20.8,46.3) | 60.7(42.6,78.8) | 87.3(82.7,91.0) |
| HPV16/58/33 | 95.6(92.0,97.9) | 25.7(16.0,37.6) | 64.3(46.5,82.0) | 80.5(75.3,85.1) |
| HPV16/58/33/52 | 96.4(92.3,98.7) | 17.1(11.0,24.7) | 78.6(59.1,91.7) | 59.9(53.8,65.9) |
| HPV16 & Cytology | 97.2(94.1,99.0) | 31.0(20.5,43.1) | 78.6(59.1,91.7) | 81.2(75.9,85.8) |
| HPV16/58 & Cytology | 97.0(93.7,98.9) | 25.9(17.0,36.6) | 78.6(59.1,91.7) | 75.8(70.1,80.9) |
| HPV16/33 & Cytology | 97.6(94.5,99.2) | 28.8(19.2,40.0) | 82.1(63.1,93.9) | 78.1(72.6,83.0) |
| HPV16/58/33 & Cytology | 97.4(94.1,99.2) | 24.5(16.2,34.4) | 82.1(63.1,93.9) | 72.7(66.9,78.0) |
| HPV16/58/33/52 & Cytology | 98.6(95.1,99.8) | 17.9(12.1,25.2) | 92.9(76.5,99.1) | 54.2(48.2,60.3) |
HPV: Human papillomavirus; CIN: Cervical intraepithelial neoplasia; NPV: Negative predictive value; PPV: Positive predictive value.