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. 2016 Aug 23;7(38):62503–62519. doi: 10.18632/oncotarget.11526

Figure 1. NQO1 substrates TSA and β-lap induce FOXO1 activation.

Figure 1

A549 cells were treated with 40 μM of TSA or 5 μM of β-lap for 2 h and harvested at indicated time. The mRNA level A. and protein level B. of FOXO1. FOXO1 protein translocation from cytoplasm into nucleus was observed by confocal microscope C. The mRNA level of MnSOD D. The protein levels of BIM, BCL-6, TRAIL and FasL E. Data are shown as mean ± SEM of three independent experiments (*P<0.05, **P<0.01, TSA or β-lap treatment compared with control group).