Skip to main content
. 2016 Aug 23;7(38):62607–62618. doi: 10.18632/oncotarget.11546

Figure 5. Micelles-PTX combined with IMA pretreatment significantly inhibited the growth of tumors.

Figure 5

A. Tumor growth curve and B. mouse body weight curve throughout the experiment. C. Tumor xenografts images and D. tumor weights at the study end point. * P<0.05, *** P<0.001 compared with the control or IMA group, # P<0.01 compared with the Control+Micelles-PTX group. E. H & E staining of A549 xenograft slices from mice after various treatments. Black, blue and red arrows indicated karyopyknosis, karyorrhexis and karyolysis, respectively. The bar indicated 100 μm. Mouse models with size-matched A549 tumor xenografts were randomly assigned into four groups (n=6) and received oral treatment of IMA (50 mg/kg) or deionized water for two weeks followed by Micelles-PTX treatment. After Micelles-PTX treatment started, IMA or deionized water treatment was continued for another week. Micelles-PTX treatment was continued every third day for five times with the PTX dose of 5 mg/kg.