Table 2. Univariate and multivariable analyses for overall survival.
| Variables | Univariate analysis | Multivariate analysis | |
|---|---|---|---|
| P-value | HR (95% CI) | P-value | |
| Low MPV | 0.045 | 2.44 (1.11-5.38) | 0.026 |
| Age > 60 years | 0.050 | 1.52 (0.68-3.38) | 0.311 |
| Male | 0.851 | ||
| ECOG PS > 2 | 0.180 | ||
| Comorbidity | |||
| Diabetes | 0.746 | ||
| History of thrombosisa | 0.434 | ||
| Complication | |||
| Arterial thrombosis during follow-up | 0.328 | ||
| ISS stage III | 0.584 | ||
| Hemoglobin < 100 g/L | 0.814 | ||
| Platelets < 150×109/L | 0.486 | ||
| Creatinine > 176.8 umol/L | 0.614 | ||
| Calcium > 2.75 mmol/L | 0.470 | ||
| Albumin < 35 g/L | 0.896 | ||
| β2-microglobulin > 5.5 ug/mL | 0.509 | ||
| LDH ≥ (2× ULN) | 1.000 | ||
| BM plasma cell ≥ 30% | 0.003 | 3.69 (1.58-8.60) | 0.002 |
| Cytogenetics (FISH) | |||
| 1q21 amplification | 0.283 | ||
| 13q14 deletion | 0.962 | ||
| p53 deletion | 0.327 | ||
| IgH rearrangement | 0.205 | ||
| Novel drug-based treatment regimen | 0.664 | ||
| SCT | 0.766 | ||
MPV, mean platelet volume; ECOG, Eastern Cooperative Oncology Group; PS, performance status; ISS, international staging system; LDH, lactate dehydrogenase; ULN, upper limit of normal value; BM, bone marrow; FISH, fluorescent in situ hybridization; SCT, stem cell transplantation; HR, hazard ratio; 95% CI, 95% confidence interval.
a
including the history of VTE and arterial event.