Table 4. Multivariate analysis of probable prognostic factors in disease free survival.
| Variables | LRFS | DMFS | DFS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Distance from anal verge ≤ 5 cm vs. > 5cm |
- | 1.28 | 0.53-3.11 | 0.58 | 0.96 | 0.42-2.21 | 0.93 | ||
| Pathologic node stage N1 vs. N2 |
3.48 | 1.03-11.70 | 0.04 | 1.36 | 0.69-2.69 | 0.38 | 1.90 | 1.04-3.47 | 0.04 |
| Type of surgery LAR vs. APR |
- | 2.18 | 0.87-5.49 | 0.10 | 2.73 | 1.14-6.56 | 0.02 | ||
| Lymphovascular invasion No vs. Yes |
2.78 | 0.91-8.49 | 0.07 | - | - | ||||
|
P53 ≤20 vs. >20 |
- | 1.86 | 0.92-3.77 | 0.08 | 1.54 | 0.83-2.89 | 0.17 | ||
| Nuclear survivin ≤80 vs. >80 |
3.23 | 1.06-9.81 | 0.04 | 2.11 | 1.08-4.12 | 0.03 | 2.46 | 1.35-4.45 | 0.003 |
| Cytoplasmic survivin ≤80 vs. >80 |
- | 2.65 | 1.35-5.20 | 0.005 | 2.16 | 1.17-4.00 | 0.01 | ||
Abbreviations. HR, hazard ratio; 95% CI, 95% confidence interval; CEA, carcinoembryonic antigen; AJCC, American Joint Committee on Cancer; LAR, low anterior resection; APR, abdomino-perineal resection.
Multivariate analysis was performed with only significant prognostic factors in the univariate analysis (LRFS: Pathologic node stage, Lymphovascular invasion, Nuclear survivin; DMFS: Distance from anal verge, Pathologic node stage, Type of surgery, P53, Nuclear survivin, Cytoplasmic survivin; DFS: Distance from anal verge, Pathologic node stage, Type of surgery, P53, Nuclear survivin, Cytoplasmic survivin).