Fig 5. Using a combination of doxorubicin and CXCR4-KLA could synergistically inhibit invasion, migration, and colonization of OVC.
(A-C) Representative images showing the wound healing, migration, and colony formation assays on A2780/ADR, CXCR4High, and CXCR4Low. The cells were treated with vehicle alone, doxorubicin alone, CXCR4-KLA alone and a combination of the drug and peptide. (D-F) The results were also presented quantitatively to reflect the percentage and number of cells that invaded the wounds and migrated through the chambers, as well as the number of colonies formed. The results expressed on the graph represent the means ± SD of three independent experiments (t-test, *p<0.05, **p<0.01, ***p<0.001).