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. 2017 Feb 14;12(2):e0169959. doi: 10.1371/journal.pone.0169959

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© 2017 Zhai et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) Expression of CacyBP/SIP was reduced by CacyBP/SIPsi1 in both HT29- and SW480 cell lines. Control cell lines were established in HT29 and SW480 by stably transfected with a negative control siRNA transgene (pSilencer). Actin was used as an internal control. (B) Knockdown of CacyBP/SIP abolished the stimulatory effect of gastrin on the proliferation. This experiment was carried out as described in Fig 2A. (C) Inhibition of CacyBP/SIP expression results in decreased anchorage-dependent growth induced by gastrin. This experiment was carried out as described in Fig 2B. (D, E) Proliferation rate of stably transfected CacyBP/SIPsi cells are slower than the corresponding control cell lines for both HT29 and SW480. The relative proliferation rate was measured by MTT assay and normalized by HT29 or SW480 control cells for each day.