Figure 11. The dimerization region and the activation segment are disproportionally highly conserved across HUWE1 orthologues.
Sequence alignment of 20 selected HUWE1 orthologues, as output by Clustal Omega (RRID:SCR_001591; http://www.ebi.ac.uk/Tools/msa/clustalo/) and sorted by their degree of sequence identity with the HECT domain of the human protein (top row). The illustration was prepared with Geneious Basic (RRID:SCR_010519) (Kearse et al., 2012). The alignment contains regions homologous to residues 3759 to 3992 of human HUWE1, that is, the region preceding the HECT domain.