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Bumetanide decreases seizure susceptibility in glioma-implanted mice.
The latency to seizure onset (a) and the percent time exhibiting epileptiform activity (b) for two hours following kainic acid (10 mg/kg) administration in vehicle and bumetanide-treated mice implanted with a glioma two weeks prior compared to sham-implanted mice. n = 6 mice per experimental group. * Denotes a p value < 0.05 determined using a two-way ANOVA.
