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. Author manuscript; available in PMC: 2017 Dec 28.
Published in final edited form as: J Control Release. 2016 Nov 5;244(Pt A):14ā€“23. doi: 10.1016/j.jconrel.2016.11.001

Figure 7.

Figure 7

A schematic diagram illustrating the possible interplay between the EGFR and CK2 signaling pathways that regulate GBM cell proliferation. An attached ā€œPā€ indicates phosphorylation. PD-L1 - programmed death-ligand 1, EGFR - epidermal growth factor receptor, heat shock protein 90 - Hsp90, Cdc37 - co-chaperone of Hsp90, Akt - a serine/threonine protein kinase, CK2 - protein kinase CK2, NICD - intracellular domain of the Notch receptor, PTEN - tensin homolog deleted on chromosome 10, Gli1 - glioma-associated oncogene homolog 1 (zinc finger protein). Nestin and c-Myc are cancer stem cell markers important for glioma invasion. Catenins are cell-cell adhesion proteins; Ī²-catenin also regulates transcription and is part of the Wnt signaling pathway that regulates cell proliferation and migration.