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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: Anal Chem. 2016 Dec 30;89(2):1299–1306. doi: 10.1021/acs.analchem.6b04105

Figure 1. A generalized scheme of the QuARKMod platform.

Figure 1

QuARKMod has been validated for use with a broad range of cell and tissue samples. Following protein digestion, the absolute concentrations of PTMs can be determined in a given sample. In addition, using data-dependent scanning, we outline a method for the discovery of novel or low-abundance Lys and Arg PTMs in the same biological samples.