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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: Anal Chem. 2016 Dec 30;89(2):1299–1306. doi: 10.1021/acs.analchem.6b04105

Figure 3. Quantitation of Lys and Arg PTMs on isolated histones.

Figure 3

(a) To measure histone-specific changes, histones were purified using an offline HPLC method, resulting in significant separation of each core histone. (b) Purified histones collected from HEK293 cells demonstrate varying degrees of Lys and Arg PTMs.