Fig. 3. Comparisons of the serum microRNAs (miRNAs) level in breast cancer patients across different TNM stages. The serum levels of miR-21 (A), miR-125b (B), miR-145 (C), and miR-365 (E) showed no difference across different TNM stages. Compared to stages I and II, the serum miR-155 level was lower in breast cancer patients at stage III (D). In comparison with healthy controls, the miR-21 level was remarkably higher in breast cancer patients at any TNM stage (A), miR-155 was significantly higher at stages I and II (D), whereas miR-365 was significantly lower at stages I and III (E). Data are expressed as mean ± standard deviation. NS, not significant.