Fig. 4. Comparisons of the serum miRNAs levels in breast cancer patients with different hormone status. (A-E) The serum levels of miRNAs were compared in various groups of breast cancer patients classified by hormone status including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) as well as p53. The serum level of miR-145 was significantly higher in PR-positive patients as compared with PR negative. The number for each group was indicated in the images. Data are expressed as mean ± standard deviation. (F) The positive rates of miR-21, miR-155, and miR-365 as well as CEA and CA153 in breast cancer patients. Positivity of the three miRNAs was determined based on the confidence intervals (CI). The value of miR-21 and miR-155 level ≥ the CI, and the value of miR-365 level ≤ the CI, was considered positive.