Fig. 1.

Conceptual diagram of the integration of phosphoproteomics into prostate cancer clinical management. a A biopsy of the tumor is taken from a metastatic castration-resistant prostate cancer (mCRPC) patient. b The biopsy specimen is processed to generate its omics data. c The omics data is integrated to produce a personalized pathway signature. d Drug targets are identified from this signature. e Available drugs are assessed for each drug target. f The drug or combinations of drugs that block the target are selected for treatment in addition to standard of care as an arm in a clinical trial