. Author manuscript; available in PMC: 2018 Mar 1.

Published in final edited form as: Anesthesiology. 2017 Mar;126(3):482–494. doi: 10.1097/ALN.0000000000001512

Table 1.

Statistical analysis for EEG power frequencies during recovery

	Delta (0.5–4 Hz)			Theta (4–10 Hz)			Alpha (10–15 Hz)			Beta (15–25 Hz)

	F(DFn, DFd)		p-value	F(DFn, DFd)		p-value	F(DFn, DFd)		p-value	F(DFn, DFd)		p-value

Treatment	F(1,180) = 11.42	^*	0.0009	F(1,180) = 4.188	^*	0.0422	F (1, 180) = 20.95	^*	<0.0001	F (1, 180) = 2.329	ns	0.1288
Time Point	F(9,180) = 0.5377	ns	0.8457	F(9,180) = 0.2997	ns	0.9741	F (9, 180) = 1.504	ns	0.1495	F (9, 180) = 1.566	ns	0.1285
Interaction	F(9,180) = 2.961	^*	0.0026	F(9,180) = 2.481	^*	0.0108	F (9, 180) = 1.189	ns	0.3047	F (9, 180) = 1.43	ns	0.1782

Sidak's multiple comparisons test	Saline vs Ketamine		p-value	Saline vs Ketamine		p-value	Saline vs Ketamine		p-value	Saline vs Ketamine		p-value

	Recovery 1	^*	<0.0001	Recovery 1	^*	<0.0001	Recovery 1	ns	0.8837	Recovery 1	^*	0.0033
	Recovery 2	ns	0.1898	Recovery 2	ns	0.7652	Recovery 2	ns	0.9060	Recovery 2	ns	>0.9999
	Recovery 3	ns	0.9459	Recovery 3	ns	>0.9999	Recovery 3	ns	0.9060	Recovery 3	ns	>0.9999
	Recovery 4	ns	0.9986	Recovery 4	ns	>0.9999	Recovery 4	ns	0.7420	Recovery 4	ns	>0.9999
	Recovery 5	ns	0.9874	Recovery 5	ns	>0.9999	Recovery 5	ns	0.7061	Recovery 5	ns	0.9859
	Recovery 6	ns	>0.9999	Recovery 6	ns	>0.9999	Recovery 6	ns	0.4399	Recovery 6	ns	>0.9999
	Recovery 7	ns	0.9932	Recovery 7	ns	0.9761	Recovery 7	ns	0.5824	Recovery 7	ns	>0.9999
	Recovery 8	ns	>0.9999	Recovery 8	ns	>0.9999	Recovery 8	ns	0.3532	Recovery 8	ns	0.9989
	Recovery 9	ns	>0.9999	Recovery 9	ns	>0.9999	Recovery 9	^*	0.0319	Recovery 9	ns	>0.9999
	Recovery 10	ns	>0.9999	Recovery 10	ns	>0.9999	Recovery 10	ns	0.7925	Recovery 10	ns	>0.9999

Two-way ANOVA	Low Gamma (25–55 Hz)			Medium Gamma (65–125 Hz)			High Gamma (125–175 Hz)			Ultra-High Gamma (185–250 Hz)

	F(DFn, DFd)		p-value	F(DFn, DFd)		p-value	F(DFn, DFd)		p-value	F(DFn, DFd)		p-value

Treatment	F (1, 180) = 122.3	^*	<0.0001	F (1, 180) = 60.65	^*	<0.0001	F (1, 180) = 49.38	^*	<0.0001	F (9, 180) = 1.938	^*	0.0492
Time Point	F (9, 180) = 10.61	^*	<0.0001	F (9, 180) = 8.266	^*	<0.0001	F (9, 180) = 4.846	^*	<0.0001	F (9, 180) = 0.9208	ns	0.5083
Interaction	F (9, 180) = 5.305	^*	<0.0001	F (9, 180) = 2.787	^*	0.0044	F (9, 180) = 3.06	^*	0.0020	F (1, 180) = 3.58	^*	0.0601

Sidak's multiple comparisons test	Saline vs Ketamine		p-value	Saline vs Ketamine		p-value	Saline vs Ketamine		p-value	Saline vs Ketamine		p-value

	Recovery 1	^*	<0.0001	Recovery 1	^*	<0.0001	Recovery 1	ns	0.7918	Recovery 1	ns	0.2143
	Recovery 2	^*	<0.0001	Recovery 2	^*	<0.0001	Recovery 2	^*	<0.0001	Recovery 2	ns	0.8167
	Recovery 3	^*	<0.0001	Recovery 3	^*	0.0167	Recovery 3	^*	<0.0001	Recovery 3	ns	>0.9999
	Recovery 4	^*	0.0007	Recovery 4	ns	0.4190	Recovery 4	ns	0.0575	Recovery 4	ns	0.9998
	Recovery 5	^*	0.0010	Recovery 5	ns	0.0645	Recovery 5	ns	0.0575	Recovery 5	ns	>0.9999
	Recovery 6	ns	0.1676	Recovery 6	ns	0.9671	Recovery 6	ns	0.8743	Recovery 6	ns	>0.9999
	Recovery 7	ns	0.3230	Recovery 7	ns	0.4864	Recovery 7	ns	0.6089	Recovery 7	ns	0.9998
	Recovery 8	ns	0.4702	Recovery 8	ns	0.3560	Recovery 8	ns	0.9896	Recovery 8	ns	0.9998
	Recovery 9	ns	0.9088	Recovery 9	ns	0.1643	Recovery 9	ns	0.9212	Recovery 9	^*	0.0200
	Recovery 10	ns	>0.9999	Recovery 10	ns	0.9999	Recovery 10	ns	>0.9999	Recovery 10	ns	0.6067

Two-way ANOVA with Sidak’s multiple comparisons test.

P-value <0.05 considered significant (*) different;

ns: non-significant; vs: versus.