Table 1.
Functional role of proteins encoded by the DosR genes.
| Predicted functional group | Gene | Reported/predicted functional role of the encoded protein |
| Stress response | Rv2623 | Regulates bacillary growth of Mtb by modulating ATP-binding (174). Biomarker for the diagnosis of latent tuberculosis meningitis (175) |
| Rv3134c | Associates with devRS to form an operon that mediates the expression of DevR target genes (176) | |
| Rv2031c | Alpha-crystallin (Hsp-X), a master regulator of Rv-2018-2031 operon (177); blocks the differentiation of monocytes to dendritic cells (178) | |
| Rv2624c, Rv1996, Rv2005c, Rv2028c | Not yet characterized | |
| Proteases and transport | Rv2625c | Metalloprotease (Rip3); required for early phases of pulmonary tuberculosis infection (179) |
| Rv1997 | Not yet characterized | |
| Rv1735c | Immunogenic (169) | |
| Rv1733c | Enhances humoral and cellular immunity (180) | |
| Host–pathogen interactions | Rv2626c | Modulates macrophage effector functions and delayed hypersensitivity (171). Diagnostic marker for tuberculosis (181) |
| Rv2004c | Binds specifically to U397 macrophages and A549 epithelial cells to modulate immune responses (182) | |
| Sensor kinases and transcriptional regulation | Rv3132c (DosS), Rv2027c (DosT)Rv3133c (DosR) | Form a two sensor kinase system (183) |
| Rv0081 | Predicted to involve in encoding of formate Hydrogenylase complex (Rv0081-Rv0088 locus) (184); highly immunogenic in African populations (169) | |
| Cell wall and protein synthesis | Rv0079 | RafH (ribosome-associated factor during hypoxia); stabilizes ribosome under stress conditions (6, 185); inducer of T-cell responses (186) |
| Rv0574c | A pyroglutamate synthase-like protein, modulates poly-α-l-glutamine content in the cell walls to maintain cell integrity under hostile conditions (187) | |
| Rv1738 | Shutdown of ribosomal protein synthesis (188) | |
| Nucleotide metabolism and repair | Rv2630 | Immunogenic in patients with active pulmonary tuberculosis; exact role in nucleotide metabolism and repair are yet to be proven in vivo (189) |
| Rv2631 | RNA-splicing ligase RtcB; function not yet characterized | |
| Rv0570 | Putative vitamin B12 dependent ribonucleoside-diphosphate reductase; immunogenic (134) | |
| Rv0571c | Putative phosphoribosyltransferase; function not yet characterized | |
| Nitrogen metabolism | Rv3131 | Putative NAD(P)H nitroreductase and immunogenic in nature (169, 190) |
| Rv2032 | Putative NADP(H) nitroreductase (191); Potent inducer of host cytokines (192, 193) | |
| Rv1737c, Rv1736c | Nark2 and NarkX (encoded by Rv1737c and Rv1736c, respectively) are nitrate/nitrite transporters required during mycobacterial anerobic dormancy (194); immunogenic and potent diagnostic markers of tuberculosis (169) | |
| Rv3127 | Not yet characterized | |
| Redox balance | Rv0573c | Predicted to involve in biosynthesis and recycling of nicotinamide; lmmunogenic (195) |
| Rv1812c | Nitrogen metabolism during stress (172) | |
| Rv3130c | Putative Diacylglycerol O-acyltransferase; facilitates accumulation of triacylglycerol under stress (196) | |
| Rv2029c | Putative 6-Phosphofructokinase (PfkB); induces cytokine production (197) | |
| Rv1734c, Rv2006, Rv1998c, Rv2003c, Rv2007c | Not yet characterized | |
| Hypothetical proteins | Rv2628 | Immune-mediated protection against tuberculosis (198) |
| Rv2627c | Delays mycobacterial growth (199) | |
| Rv2629, Rv3126c, Rv0569, Rv0572c, Rv0080, Rv2030c, Rv3128c, Rv1813c | Not yet characterized | |