Skip to main content
. 2016 Dec 11;595(4):1377–1392. doi: 10.1113/JP273012

Figure 2. Local application of physostigmine (PHYSO, 5 mm, 200 nl) in pFRG induces long lasting ABD recruitment and active expiration.

Figure 2

A, long trace recordings of ∫DIAEMG, ∫GGEMG and ∫ABDEMG, respiratory airflow and tidal volume (V T) during local bilateral application of PHYSO (black arrows indicate time of injections on the two sides of the ventrolateral medulla). B, details of respiratory traces before (left) and after PHYSO application (centre and right). Note progressive activation of expiratory modulated ABDEMG activity. C, single experiment data (grey) and averaged data (black) on the effect of bilateral application of PHYSO on ∫DIAEMG, ∫GGEMG and ∫ABDEMG, breaths per minute (bpm) and tidal volume (V T). EMG and tidal volume data are normalized (n) to control values (CTR) and asterisks indicate statistical significance (P < 0.05) relative to pre‐injection CTR values.